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Peer-Reviewed Publication
AJNR Am J Neuroradiol2018;39(6):1008-1016.June 1, 2018Journal Article

Multisite Concordance of DSC-MRI Analysis for Brain Tumors: Results of a National Cancer Institute Quantitative Imaging Network Collaborative Project.

K M Schmainda1, M A Prah2, S D Rand2,3, Y Liu4, B Logan4, M Muzi3, S D Rane2, X Da5, Y-F Yen6, J Kalpathy-Cramer6, T L Chenevert7, B Hoff7, B Ross7, Y Cao8, M P Aryal8, B Erickson9, P Korfiatis9, T Dondlinger10, L Bell11, L Hu12, P E Kinahan3, C C Quarles11
1From the Department of Radiology (K.M.S., M.A.P., S.D.R.) kathleen@mcw.edu.
2From the Department of Radiology (K.M.S., M.A.P., S.D.R.).
3Department of Radiology (M.M., S.D.R., P.E.K.), University of Washington, Seattle, Washington.
4Division of Biostatistics (Y.L., B.L.), Institute for Health and Society, Medical College of Wisconsin, Milwaukee, Wisconsin.
5Department of Radiology (X.D.), Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
6Athinoula A. Martinos Center for Biomedical Imaging (Y.-F.Y., J.K.-C.), Department of Radiology, Harvard Medical School/Massachusetts General Hospital, Charlestown, Massachusetts.
7Department of Radiology (T.L.C., B.H., B.R.).
8Departments of Radiation Oncology, Radiology, and Biomedical Engineering (Y.C., M.P.A.), University of Michigan, Ann Arbor, Michigan.
9Department of Radiology (B.E., P.K.), Mayo Clinic, Rochester, Minnesota.
10Imaging Biometrics LLC (T.D.), Elm Grove, Wisconsin.
11Division of Imaging Research (L.B., C.C.Q.), Barrow Neurological Institute, Phoenix, Arizona.
12Department of Radiology (L.H.), Mayo Clinic, Scottsdale, Arizona.
PubMed PMC DOI PDF

Abstract

BACKGROUND AND PURPOSE: Standard assessment criteria for brain tumors that only include anatomic imaging continue to be insufficient. While numerous studies have demonstrated the value of DSC-MR imaging perfusion metrics for this purpose, they have not been incorporated due to a lack of confidence in the consistency of DSC-MR imaging metrics across sites and platforms. This study addresses this li…

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