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Peer-Reviewed Publication
Per Med2013;10(5):497-507.July 1, 2013Journal Article

Pathology-supported genetic testing directed at shared disease pathways for optimized health in later life.

Maritha J Kotze1, David P van Velden2, Karien Botha3, Casper H Badenhorst4, Heloise Avenant5, Susan J van Rensburg2, Frans J Cronjé6
1Department of Pathology, Faculty of Medicine & Health Sciences, University of Stellenbosch, Tygerberg, South Africa. maritha@sun.ac.za.
2Department of Pathology, Faculty of Medicine & Health Sciences, University of Stellenbosch, Tygerberg, South Africa.
3Paarl Medical Centre, Paarl, South Africa.
4Integrated Health, Pretoria, South Africa.
5Blueprint Health (Pty) Ltd, Cape Town, South Africa.
6Department of Interdisciplinary Health Sciences, Faculty of Medicine & Health Sciences, University of Stellenbosch, Tygerberg, South Africa.
PubMed DOI

Abstract

Several chronic, noncommunicable diseases share common genetic risk factors. These include cardiovascular disease and several neurological and psychiatric disorders, as well as some forms of cancer. Clinical compartmentalization and the challenges of translational research have delayed the implementation of personalized medicine. To overcome these limitations, a pathology-supported genetic testing…

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