The NRP1 migraine risk variant shows evidence of association with menstrual migraine.

Charmaine E Pollock¹, Heidi G Sutherland¹, Bridget H Maher¹, Rodney A Lea¹, Larisa M Haupt¹, Alison Frith², E Anne MacGregor³, Lyn R Griffiths⁴

¹Genomics Research Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.

²Clinithink Limited, Bridgend, UK.

³Centre for Neuroscience & Trauma, Blizard Institute of Cell and Molecular Science, London, UK.

⁴Genomics Research Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia. lyn.griffiths@qut.edu.au.

PubMed PMC DOI PDF

Abstract

BACKGROUND: In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificity to MO, the study did not test the loci with respect to other subtypes of migraine. This study aimed to test the hypothesis that single nucleotide polymorphisms (SNPs) robustly a…

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