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Peer-Reviewed Publication
J Pharm Sci2018;107(5):1304-1312.May 1, 2018Journal Article

Measurement of Average Aggregate Density by Sedimentation and Brownian Motion Analysis.

Richard E Cavicchi1, Jason King2, Dean C Ripple3
1Bioprocess Measurements Group, National Institute of Standards and Technology, Gaithersburg, Maryland 20899. Electronic address: rcavicchi@nist.gov.
2Bioprocess Measurements Group, National Institute of Standards and Technology, Gaithersburg, Maryland 20899; XSOLIS, Nashville, Tennessee 37217.
3Bioprocess Measurements Group, National Institute of Standards and Technology, Gaithersburg, Maryland 20899.
PubMed PMC DOI PDF

Abstract

The spatially averaged density of protein aggregates is an important parameter that can be used to relate size distributions measured by orthogonal methods, to characterize protein particles, and perhaps to estimate the amount of protein in aggregate form in a sample. We obtained a series of images of protein aggregates exhibiting Brownian diffusion while settling under the influence of gravity in…

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