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Peer-Reviewed Publication
Eur J Nucl Med Mol Imaging2016;43(12):2201-2210.November 1, 2016Journal Article

Kinetic analysis of the translocator protein positron emission tomography ligand [18F]GE-180 in the human brain.

Claire Feeney1,2, Gregory Scott3, Joel Raffel3, S Roberts3, Christopher Coello3, Amy Jolly3, Graham Searle3, A P Goldstone3, David J Brooks3,4, Richard S Nicholas3, William Trigg5, Roger N Gunn3, David J Sharp3
1Division of Brain Sciences, Hammersmith Hospital Campus, Imperial College London, London, UK. c.feeney@imperial.ac.uk.
2Computational, Cognitive and Clinical Neuroimaging Laboratory, Hammersmith Hospital, 3rd Floor, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK. c.feeney@imperial.ac.uk.
3Division of Brain Sciences, Hammersmith Hospital Campus, Imperial College London, London, UK.
4Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
5GE Healthcare Ltd, Amersham, UK.
PubMed PMC DOI PDF

Abstract

PURPOSE: PET can image neuroinflammation by targeting the translocator protein (TSPO), which is upregulated in activated microglia. The high nonspecific binding of the first-generation TSPO radioligand [11C]PK-11195 limits accurate quantification. [18F]GE-180, a novel TSPO ligand, displays superior binding to [11C]PK-11195 in vitro. Our objectives were to: (1) evaluate tracer characteristics of [1…

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