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Peer-Reviewed Publication
Molecules2015;20(12):20979-97.November 25, 2015Journal Article

DNA Aptamers in the Diagnosis and Treatment of Human Diseases.

Qinchang Zhu1, Ge Liu2, Masaaki Kai3
1Faculty of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. zhu_qinchang@hotmail.com.
2Department of Genomic Epidemiology, Research Center for Environment and Developmental Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan. lggege_15@hotmail.com.
3Faculty of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. ms-kai@nagasaki-u.ac.jp.
PubMed PMC DOI PDF

Abstract

Aptamers have a promising role in the field of life science and have been extensively researched for application as analytical tools, therapeutic agents and as vehicles for targeted drug delivery. Compared with RNA aptamers, DNA aptamers have inherent advantages in stability and facility of generation and synthesis. To better understand the specific potential of DNA aptamers, an overview of the pr…

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