Peer-Reviewed Publication
IEEE J Sel Top Quantum Electron2014;20(2)March 1, 2014Journal Article
High Resolution Phase-Sensitive Magnetomotive Optical Coherence Microscopy for Tracking Magnetic Microbeads and Cellular Mechanics.
Vasilica Crecea1, Benedikt W Graf2, Taewoo Kim3, Gabriel Popescu4, Stephen A Boppart5
1Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( crecea@illinois.edu ).
2University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA. He is now with NinePoint Medical, Cambridge, MA 02139 USA ( bgraf@ninepointmedical.com ).
3Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( tkim44@illinois.edu ).
4Departments of Electrical and Computer Engineering and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( gpopescu@illinois.edu ).
5Departments of Electrical and Computer Engineering, Bioengineering, and Internal Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA ( boppart@illinois.edu ).
Abstract
We present a real-time multimodal near-infrared imaging technology that tracks externally induced axial motion of magnetic microbeads in single cells in culture. The integrated multimodal imaging technique consists of phase-sensitive magnetomotive optical coherence microscopy (MM-OCM) and multiphoton microscopy (MPM).MPMis utilized for the visualization of multifunctional fluorescent and magnetic…
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