Medication-Supported Weight Management
GLP-1 medication combined with lifestyle coaching for sustainable weight loss
Company profile
Company profile
Second Nature is a digital health company that provides comprehensive weight management and metabolic health services combining medical treatment with behaviour change support. The company offers a whole-person approach that integrates GLP-1 medications (such as Wegovy and Mounjaro), personalised nutrition coaching from registered nutritionists, habit formation tools, and community support to help people achieve sustainable weight loss. Founded by scientists Chris and Mike who were frustrated with traditional calorie-counting and fad diets, Second Nature has developed a clinically proven programme that helps 9 out of 10 people lose weight and keep it off. The programme provides daily educational articles on nutrition science and psychology, hundreds of recipes catering to all dietary preferences, tracking tools, and ongoing support from registered nutritionists. Second Nature serves over 300,000 NHS patients and is used by more than half of all NHS Health and Care boards in the UK, making it the first app-based behaviour change service commissioned by the NHS. The company also partners with health insurers like Vitality Insurance and employers. Their services span self-guided weight management, Tier 2 and Tier 3 weight management programmes, medication-supported weight loss, type 2 diabetes prevention, and type 2 diabetes management. Clinical outcomes show members maintain an average 6.2kg weight loss at 12 months, with 40% of participants reducing HbA1c levels below the type 2 diabetes threshold. The company's research has been published in 13 peer-reviewed studies across leading medical journals including the British Medical Journal, Obesity, and Diabetic Medicine.
Company description Second Nature official website
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01 · Operating footprint
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Cloud Saas deployment with recorded integration context.
Company milestones
Supported over 300,000 NHS referrals. Commissioned by more than half of all NHS Health and Care boards. Featured on ITV's This Morning. Expanded to US market with medication-supported weight loss programme.
Partnerships
02 · Flagship portfolio
Selected source-backed Company products and the available commercial context.
GLP-1 medication combined with lifestyle coaching for sustainable weight loss
App-based behaviour change programme for building healthy habits at scale
Personalised lifestyle coaching from registered nutritionists and dietitians
Intensive multidisciplinary service for complex obesity cases
Intensive lifestyle coaching to reduce type 2 diabetes risk
Personalised service for managing type 2 diabetes through weight loss
03 · Research intelligence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
Publications, clinical validation, and regulatory records connected to this Company appear here.
Research
Primary care diabetes · Feb 1, 2026
A Remotely Delivered Weight Management Service to Support Existing Obesity Services in the UK National Health Service: Preliminary Findings From an Early-Stage Service Evaluation.JMIR formative research · Oct 15, 2025
Semaglutide and Tirzepatide in a Remote Weight Management Program: 12-Month Retrospective Observational Study.JMIR formative research · Sep 12, 2025
A Remotely Delivered GLP-1RA-Supported Specialist Weight Management Program in Adults Living With Obesity: Retrospective Service Evaluation.JMIR formative research · Jun 30, 2025
Optimising a digitally delivered behavioural weight loss programme: study protocol for a factorial cluster randomised controlled trial.Trials · Jul 13, 2024
Patterns in bird and pollinator occupancy and richness in a mosaic of urban office parks across scales and seasons.Ecology and evolution · Mar 1, 2024
Clinical validation
No linked records are currently available.
Regulatory
No linked records are currently available.
04 · Company-reported outcomes
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
NHS patients in published BMJ study
Within first 3 months of programme
At 12 months across programme participants
Clinical programme outcomes
With most effective GLP-1 medication treatment (SURMOUNT-4 trial reference)
Personal weight loss journey after years of unsuccessful attempts
19 kg weight loss in 9 months
Personal weight loss journey with medication-supported programme
38 kg weight loss in 9 months
Digital diabetes prevention and weight management services delivered at scale across NHS Health and Care boards
6.2kg average weight loss and 2.2mmol/mol HbA1c reduction after 12 months; 40% reduce HbA1c below type 2 diabetes threshold; supported over 300,000 NHS referrals
Personal weight loss journey with medication-supported programme
32 kg weight loss in 12 months; clothing size reduced from 5XL to Large
Weight management and health improvement benefit for insurance clients
Chosen as trusted partner to support tens of thousands of insurance clients with health goals
05 · Leadership
Leadership profiles and professional links from the current Company record.
06 · Company updates
Recent articles published on Second Nature's official website.
No Company updates are currently listed.
07 · HAIC coverage
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08 · Official presence
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09 · Market pathway
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Market context
Companies using AI to optimize metabolic health, provide personalized nutrition recommendations, or analyze metabolic responses to food for generally healthy or non-diabetic populations. Emphasizes wellness, performance optimization, and preventive health rather than management of a diagnosed disease.
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