Preliminary study on early microvascular ingrowth into distracted callus during distraction osteogenesis-A non-invasive approach to explore the early growth patterns and possible mechanism of distraction osteogenesis in vivo.

Juan Li¹, Yonghong Zhang², Yutao Zhang³, Dong Wang⁴, Wei Luo⁵, Xiaojin Gao⁵, Yanping Wang⁶, Ruhao Zhang⁷, Yan Li⁴, Ze Zhang³, Xinghua Wang¹, Yanzi Qiao³, Weiwei Wu³, Bojuan Wang¹, Hongjie Zhou³, Chaoqi Wang³, Zemin Liu⁴, Wei Han³, Yanming Zhi³, Jia Li⁸, Sihe Qin⁹

¹Department of Ultrasound, Second Hospital of Shanxi Medical University, Taiyuan, 030001, China.

²Department of Orthopaedics, Second Hospital of Shanxi Medical University, Taiyuan, 030001, China. Electronic address: yhzhy@139.com.

³Shanxi Medical University, Taiyuan, 030012, China.

⁴Department of Orthopaedics, Second Hospital of Shanxi Medical University, Taiyuan, 030001, China.

⁵Guru Medical Equipment Co., Ltd., Taiyuan, 030032, China.

⁶Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen, 518063, China.

⁷China Academy of Art, Hangzhou, 310002, China.

⁸Department of Orthopaedics, Chinese PLA General Hospital, Beijing, 100853, China; National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, Beijing, 100853, China.

⁹Department of Orthopaedics, Rehabilitation Hospital of the National Research Center for Rehabilitation Technical Aids, Beijing, 100176, China.

PubMed DOI

Abstract

BACKGROUND: Distraction osteogenesis (DO) is critical for repairing large segmental bone defects. Early callus vascularization is essential for bone regeneration; however, real-time microcirculatory assessment remains lacking. This study aimed to elucidate spatiotemporal microvascular network construction in distracted callus using super-resolution contrast-enhanced ultrasound (SR CEUS) and high-f…

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