Health AI Central
Peer-Reviewed Publication
Handb Exp Pharmacol2026October 17, 2026Journal Article

Mechanistic In Vitro Transporter Modelling: A Path to Consistent Intrinsic Kinetic Inputs Suitable for IVIVE of Transporters.

Matthew D Harwood1, Mailys De Sousa Mendes1, Sibylle Neuhoff2
1Certara UK Ltd, MID3 Division, Sheffield, UK.
2Certara UK Ltd, MID3 Division, Sheffield, UK. sibylle.neuhoff@certara.com.
PubMed DOI

Abstract

A key aspect of in vitro-to-in vivo extrapolation (IVIVE) linked to physiologically based pharmacokinetic (PBPK) modelling (IVIVE-PBPK) is ensuring that input data derived from in vitro assays intrinsically reflect the compound's true properties, free from the confounding effects of assay design, model structure, or data transformation methods. Having assurance in the model inputs provides an incr…

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