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Peer-Reviewed Publication
J Immunother Cancer2026;14(10)October 15, 2026Journal Article

Distinct genomic landscapes of mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancer depending on tumor mutation burden (TMB) levels.

Jingyuan Wang1,2,3, Joanne Xiu4, Alex P Farrell4, Francesca Battaglin2, Hiroyuki Arai2, Yan Yang5, Shivani Soni2, Wu Zhang2, Joshua Millstein5, Anthony F Shields6, Axel Grothey7, Benjamin A Weinberg8, John Marshall8, Emil Lou9, Moh'd Khushman10, Davendra P S Sohal11, Michael J Hall12, Tianshu Liu1,3, Matthew James Oberley4, David Spetzler4, Heinz-Josef Lenz13
1Department of Medical Oncology, Cancer Center, Zhongshan Hospital Fudan University, Shanghai, China.
2Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
3Department of Oncology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China. Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province, Xiamen, Fujian.
4Caris Life Sciences, Phoenix, Arizona, USA.
5Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
6Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
7Gastrointestinal Cancer Research, West Cancer Center and Research Institute, Germantown, Tennessee, USA.
8Ruesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.
9Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.
10Departments of Medical Oncology, Washington University in St. Louis/Siteman Cancer Center, St. Louis, Missouri, USA.
11University of Cincinnati, Cincinnati, Ohio, USA.
12Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
13Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA lenz@med.usc.edu.
PubMed DOI

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