Health AI Central
Peer-Reviewed Publication
Neurotoxicol Teratol2026;107724.October 13, 2026Journal Article

A practical learning and memory screening test in rats using a modified Biel water maze - A multi-site validation.

Pragati S Coder1, Edward Marsden2, Donald G Stump3, Nacera Mellal4, Stephanie Clubb5, Francois van Otterdijk6, Alan M Hoberman7
1Charles River Laboratories Ashland, OH, United States of America. Electronic address: pragati.coder@crl.com.
2Charles River Laboratories Lyon, France.
3Charles River Laboratories Ashland, OH, United States of America.
4Charles River Laboratories, Montreal, Canada.
5Charles River Laboratories Edinburgh, UK.
6Charles River Laboratories 's-Hertogenbosch, the Netherlands.
7Argus International, Inc. (Formerly, Charles River Laboratories), Mechanicsville, PA, United States of America.
PubMed DOI

Abstract

Developmental and adult neurotoxicity testing is an integral part of safety assessment guidelines. A key endpoint, typically performed in rodents, is the evaluation of learning and memory (L&M). Historically, a variety of equipment and testing paradigms have been developed and used across the industry. In recent years, regulatory guidance documents have become more prescriptive and stipulate speci…

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