Health AI Central
Peer-Reviewed Publication
MedComm (2020)2026;7(10):e71055.October 1, 2026Journal Article

Transformer-Based Preoperative Invasiveness Identification and Postoperative Recurrence Risk Stratification in Stage T1N0M0 Lung Adenocarcinoma: A Multi-Center Cohort Study.

Xueyun Tan1,2, Hui Xia1,3, Delong Li4, Meifang Wang5, Na Zhan6, Yan Huang7, Mengyuan Liang8, Pei Ma9, Xiao Wang5, Yaqi Cao1,10,11, Linpeng Shi1,10,11, Liang Zhang12, Xiaoling Liu13, Lian Yang14, Quan Kong15, Sufei Wang1,10,11, Yang Jin1,10,11
1Department of Respiratory and Critical Care Medicine Hubei Province Clinical Research Center for Major Respiratory Disease Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
2Department of Respiratory and Critical Care Medicine Zhongnan Hospital of Wuhan University Wuhan China.
3Department of Respiratory and Critical Care Medicine China-Japan Friendship Hospital Beijing China.
4Hubei Key Laboratory of Optical Information and Pattern Recognition School of Optical Information and Energy Engineering Wuhan Institute of Technology Wuhan China.
5Department of Respiratory and Critical Care Medicine Shiyan Key Laboratory of Major Chronic Respiratory Disease, Taihe Hospital Hubei University of Medicine Shiyan China.
6Department of Pathology Renmin Hospital of Wuhan University Wuhan China.
7Department of Respiratory and Critical Care Medicine, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science Xiangyang China.
8Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital Zhengzhou University Zhengzhou China.
9Department of Respirology Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Diseases Guangzhou China.
10Hubei Province Key Laboratory of Biological Targeted Therapy, MOE Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
11Hubei Province Engineering Research Center for Tumor-Targeted Biochemotherapy, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
12Department of Radiology Renmin Hospital of Wuhan University Wuhan China.
13Institute of Research and Clinical Innovations Neusoft Medical Systems Co. Ltd Wuhan China.
14Department of Radiology Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
15Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of Technology Wuhan China.
PubMed PMC DOI PDF

Abstract

Surgery is the primary curative treatment for early-stage lung adenocarcinoma (LUAD), with accurate identification of tumor invasiveness critical for determining pulmonary resection extent. Due to significant variability in postoperative recurrence among early-stage LUAD patients with aggressive tumors, a more effective risk stratification system is urgently needed to improve prognosis. This study…

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