Peer-Reviewed Publication
Ophthalmol Sci2026;6(11):101386.November 1, 2026Journal Article
Opportunistic Cardiovascular Risk Assessment in the Eye Clinic: Validation of a Retinal Deep Learning-Based 10-Year Atherosclerotic Cardiovascular Disease Estimator.
Simon Nusinovici1,2,3, Heesuk Kim4, Jaewon Seo3, Tyler Hyungtaek Rim1,2,3, Qingyu Chen5, Zhiyong Lu5, Chan Joo Lee6, Yih-Chung Tham1,2,7, Dongjin Nam3,8, Sahil Thakur1,2,3, Qingsheng Peng1,9, Marco Yu1, Geunyoung Lee3, Sungha Park6, Sung Soo Kim10, Tien Yin Wong1,11,12, Wathudurage De Silva13, Tiarnan D L Keenan13, Ching-Yu Cheng1,2,7, Emily Y Chew13
1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
2Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.
3Medi-Whale Inc., Seoul, South Korea.
4Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.
5National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland.
6Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, South Korea.
7Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
8Department of Internal Medicine, Graduate School, Yonsei University College of Medicine, Seoul, South Korea.
9Clinical and Translational Sciences Program, Duke-NUS Medical School, Singapore.
10Division of Retina, Severance Eye Hospital, Yonsei University College of Medicine, Seoul, South Korea.
11Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
12School of Biomedical Engineering, Tsinghua Medicine, Tsinghua University, Beijing, China.
13Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Abstract
PURPOSE: To derive and validate a retinal 10-year atherosclerotic cardiovascular disease (ASCVD) risk estimator ("Dr Noon cardiovascular disease [CVD]") and compare its performance with the clinical gold-standard pooled cohort equation (PCE) in a US population.
DESIGN: Prospective cohort study with up to 10 years of follow-up.
PARTICIPANTS: A total of 3096 participants (aged 55-75 years) from th…
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