Health AI Central
Peer-Reviewed Publication
Int J Obes (Lond)2026October 7, 2026Journal Article

Bariatric surgery and risk of dementia and Parkinson's disease in patients with obesity.

Suhail I Shiekh1,2, Dimitris Papamargaritis3,4, Jonathan Goldney3,5, Gema Hernandes6, Melanie J Davies3,5, Kamlesh Khunti3,7, Thomas Yates3,5, Francesco Zaccardi3,7
1Diabetes Research Centre, Leicester General Hospital, College of Life Sciences, University of Leicester, Leicester, UK. sis15@leicester.ac.uk.
2Leicester Real World Evidence Unit, Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK. sis15@leicester.ac.uk.
3Diabetes Research Centre, Leicester General Hospital, College of Life Sciences, University of Leicester, Leicester, UK.
4Department of Diabetes and Endocrinology, Kettering General Hospital NHS Foundation Trust, Kettering, UK.
5NIHR Leicester Biomedical Research Centre, Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK.
6TriNetX Europe NV, Sint-Martens-Latem, Belgium.
7Leicester Real World Evidence Unit, Diabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK.
PubMed DOI

Abstract

OBJECTIVE: We aimed to evaluate the association between bariatric surgery (BS) and the incidence of dementia and Parkinson's disease. To assess consistency with established benefits of BS, we examined its association with cardiovascular disease, obesity-associated cancers, and all-cause mortality. METHODS: We conducted a longitudinal cohort study using electronic health records from TriNetX netwo…

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