Health AI Central
Peer-Reviewed Publication
Metabolism2026;156793.October 5, 2026Journal Article

Depot-specific molecular remodelling of human adipose tissue and liver following bariatric surgery revealed by longitudinal multi-omic profiling.

Niall J Dempster1, Frederik Steensgaard Gade2, Charlotte Daly3, Richard Mbasu4, Lingyan Chen4, Jiawen Dong1, Elena Gangitano5, Bruno Sgromo6, Richard S Gillies6, Sarah White1, Michelle Haylock1, Ferenc E Mózes7, Kieran Smith1, Helena Thomaides-Brears8, Stefan Neubauer7, Jeremy F Cobbold9, Ramneek Gupta4, Garry D Tan1, Leanne Hodson1, Jeremy W Tomlinson10
1Oxford Centre for Diabetes Endocrinology & Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom.
2Novo Nordisk Research Centre Oxford Ltd, Oxford, OX3 7FZ, United Kingdom; AI & Digital Innovation, Novo Nordisk A/S, Måløv, 2760, Denmark; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark.
3Novo Nordisk Research Centre Oxford Ltd, Oxford, OX3 7FZ, United Kingdom; AI & Digital Innovation, Novo Nordisk A/S, Måløv, 2760, Denmark.
4Novo Nordisk Research Centre Oxford Ltd, Oxford, OX3 7FZ, United Kingdom.
5Oxford Centre for Diabetes Endocrinology & Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom; Department of Experimental Medicine, Sapienza University of Rome, Rome, 00161, Italy; Unicamillus-Saint Camillus International University of Health Sciences, Rome, 00131, Italy.
6Department of upper GI surgery, Oxford University Hospitals, Oxford, United Kingdom.
7Oxford Centre for Clinical Magnetic Resonance Research (OCMR), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
8Perspectum, Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, United Kingdom.
9Translational Gastroenterology Unit and NIHR Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
10Oxford Centre for Diabetes Endocrinology & Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, United Kingdom. Electronic address: jeremy.tomlinson@ocdem.ox.ac.uk.
PubMed DOI

Abstract

BACKGROUND: Obesity and its complications, including metabolic dysfunction-associated steatotic liver disease, remain significant global health challenges. Bariatric surgery has established clinical benefits, but the mechanisms driving metabolic improvements are not clearly defined. METHODS: We undertook a randomised, prospective, longitudinal (1-year) study in women living with obesity to determ…

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