PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development.

Julia Raulino Lima¹, Nicha Ungvijanpunya^1,2, Qing Chen³, Hoang Quoc Hai Pham⁴, Tal Rosen¹, Greg Park¹, Mohammadreza Vantankhah¹, Steven Yen^1,5, Yang Chai¹, Amy E Merrill¹, Zhaoyang Liu¹, Jian-Fu Chen¹, Yanzhong Yang⁴, Weiqun Peng³, Jian Xu¹

¹Center for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.

²Department of Orthodontics, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

³Department of Physics, The George Washington University, Washington, DC, United States.

⁴Department of Cancer Genetics and Epigenetics, City of Hope, Duarte, United States.

⁵Children's Hospital Los Angeles, Los Angeles, United States.

PubMed DOI

Abstract

Spliceosomopathies, which are a group of disorders caused by defects in the splicing machinery, frequently affect the craniofacial skeleton and limb, but the molecular mechanism underlying this tissue-specific sensitivity remains unclear. Splicing factors and small nuclear ribonucleoproteins (snRNPs) are core components of splicing machinery, and splicing factors are further controlled by post-tra…

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