Health AI Central
Peer-Reviewed Publication
BMC Gastroenterol2026;26(1)August 8, 2026Journal Article

Characterisation of liver disease using quantitative MRI: report of the imaging arm of the ELEGANCE study.

Yi-Chun Wang1,2, Yu Jun Wong3,4, Edward Jackson5, Andrea Dennis5, Sophie Riddell5, Oi Fong Chong6, Jeremy Wei Song Choo6, Sulaiha Binte Ithnin6, Pik Eu Jason Chang7, Guan Huei Lee8,9, Marianne Anastasia De Roza10, Kalki R Chandrasekaran10, Kok Kiong Ong6, Patricia Ching Yen Chia6, Kee Tung Tan6, Ngiap Chuan Tan6, Wei Lyn Yang11, Xin Yi Yeap6, Han Chong Toh12, Cheryl Min En Chua13, Jacelyn Siou Sze Chua13, Jade Shu Qi Goh13, Yu Ki Sim13, Xin Hui Rachel Teo13, Michael Brady5,14, Pierce Kah Hoe Chow13,15,16
1Perspectum Ltd., Gemini One, 5520 John Smith Drive Oxford, Oxford, OX4 2LL, UK. Yi-Chun.Wang@perspectum.com.
2University of Oxford, Oxford, United Kingdom. Yi-Chun.Wang@perspectum.com.
3Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore.
4Medical Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore.
5Perspectum Ltd., Gemini One, 5520 John Smith Drive Oxford, Oxford, OX4 2LL, UK.
6SingHealth Polyclinics, Singapore, Singapore.
7Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore.
8Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
9Centre for Digestive Health, National University, National University Hospital, Singapore, Singapore.
10Department of Gastroenterology and Hepatology, Sengkang General Hospital, Singapore, Singapore.
11Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore, Singapore.
12Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
13Programme in Clinical and Translational Liver Cancer Research, National Cancer Centre Singapore, Singapore, Singapore.
14University of Oxford, Oxford, United Kingdom.
15Surgery Academic Clinical Program, SingHealth Duke-NUS Academic Medical Center, Singapore, Singapore.
16Department of Hepato-pancreato-biliary and Transplant Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Evolving disease aetiology and rising prevalence of chronic liver disease are driving an increase in hepatocellular carcinoma (HCC). Non-contrast quantitative MRI (qMRI) has shown promising capability for characterising liver health and risk of liver related outcomes, but has not been evaluated in HCC surveillance or specifically examined in Asian populations. We explored the character…

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