Total body and appendicular lean mass by dual-energy X-ray absorptiometry are highly associated with muscle function and bone mineral density in Becker muscular dystrophy.

Rana Halloun^1,2, Stefan Jackowski¹, Maya Scharke¹, Utkarsh J Dang³, Fahd Alshammri^1,2, Jinhui Ma⁴, Ken Gaither⁵, Thomas Fuerst⁵, Hugh J McMillan^1,2, Kerry Siminoski¹, James MacDougall⁶, Joanne Donovan⁶, Leanne M Ward^1,2

¹The Ottawa Pediatric Bone Health Research Group, Ottawa, ON, Canada.

²Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.

³Department of Health Sciences, Carleton University, Ottawa, ON, Canada.

⁴Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, On, Canada.

⁵Department of Musculoskeletal Medicine, Clario, Philadelphia, PA, USA.

⁶Clinical, Medical, and Regulatory Strategy, Edgewise Therapeutics, Boulder, CO, USA.

PubMed DOI

Abstract

IntroductionBecker muscular dystrophy (Becker) is an X-linked disorder caused by decreased or dysfunctional dystrophin. Data on Dual-energy X-ray absorptiometry (DXA)-derived body composition and the skeletal phenotype are limited. We evaluated associations between DXA-derived height-adjusted body composition and motor function and characterized areal bone mineral density (aBMD) in adolescents and…

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