Factors Facilitating Adoption of Pharmacogenetic Testing by Prescribers of Antidepressants in Four US Health Systems: A Multi-Site Cross-Sectional PGx Implementation Science Study.

Alice B Popejoy¹, Deborah Cragun², Megan C Roberts³, Lisa M Bendz⁴, Sarah Gonzales⁵, Susanne B Haga^6,7, R Ryanne Wu^7,8, Natasha J Petry^9,10, Laura B Ramsey¹¹, Ryley Uber¹², Kaniz Momin³, Nina R Sperber^5,13

¹Department of Public Health Sciences, UC Davis School of Medicine, University of California at Davis, Davis, CA 95616, USA.

²Department of Community Health Sciences, College of Public Health, University of South Florida, Tampa, FL 33612, USA.

³Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

⁴Center for Medication Policy and Drug Information, Department of Pharmacy, Duke University Hospital, Durham, NC 27710, USA.

⁵Department of Population Health Sciences, School of Medicine, Duke University, Durham, NC 27710, USA.

⁶Center for Precision Health, School of Medicine, Duke University, Durham, NC 27710, USA.

⁷Department of Medicine, Division of General Internal Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.

⁸23andMe, Palo Alto, CA 94306, USA.

⁹Sanford Health Imagenetics, Sioux Falls, SD 57105, USA.

¹⁰Department of Pharmacy Practice, North Dakota State University, Fargo, ND 58108, USA.

¹¹Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO 64108, USA.

¹²Center for Pharmacy Innovation and Outcomes, Geisinger, Danville, PA 17822, USA.

¹³Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA Health Care System, Durham, NC 27705, USA.

PubMed PMC DOI PDF

Abstract

Background: Pharmacogenetic (PGx) testing could identify actionable drug-gene interactions, reducing the risks of inappropriate prescribing of certain medications in some patients. An area of growing public health concern is rising global rates of depression and antidepressant use over the last two decades. Prior research has elucidated perspectives of healthcare providers who prescribe antidepres…

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