Peer-Reviewed Publication
Am Heart J2026;107586.August 25, 2026Journal Article
Health Status Relationship to Ischemia and Coronary Artery Disease Severity in the ISCHEMIA Trial.
Lawrence M Phillips1, Philip G Jones2, Leslee J Shaw3, Daniel B Mark4, Daniel S Berman5, Raymond Y Kwong6, Michael H Picard7, Bernard R Chaitman8, James K Min9, Jelena Celutkiene10, Gregg W Stone3, Joao Vitola11, Nagaraja Moorthy12, Philippe Gabriel Steg13, Peter Ong14, Whady A Hueb15, Paulo C Rezende15, Judith S Hochman16, David J Maron17, Harmony R Reynolds16, John A Spertus2,
1New York University Grossman School of Medicine, New York, New York, USA. Electronic address: Lawrence.Phillips@nyulangone.org.
2University of Missouri - Kansas City (UMKC)'s Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.
3Icahn School of Medicine at Mount Sinai, New York, New York, USA.
4Duke University School of Medicine, Durham, North Carolina, USA.
5Cedars-Sinai Medical Center, Log Angeles, California, USA.
6Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
7Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
8St. Louis School of Medicine, St. Louis, Missouri, USA.
9Cleerly Inc., New York, New York, USA.
10Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Centre of Innovative Medicine, Vilnius, Lithuania.
11Quanta Diagnostico, Curitiba, Brazil.
12Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore-Karnataka, Karnataka, India.
13Universite Paris-Cité, Assistance Publique-Hopitaux de Paris, and INSERM_U1148, Paris, France.
14Department of Cardiology and Angiology, Robert-Bosch-Hospital, Stuttgart, Germany.
15Instituto do Coração (InCor), Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
16New York University Grossman School of Medicine, New York, New York, USA.
17Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Abstract
BACKGROUND: The ISCHEMIA trial randomized participants with chronic coronary disease and moderate or severe ischemia by site assessment to an initial invasive strategy plus guideline-directed medical therapy (GDMT) or to an initial conservative strategy of GDMT alone. This secondary analysis examines the association of pre-randomization ischemia severity, from stress testing assessed by a core lab…
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