Peer-Reviewed Publication
medRxiv2026August 4, 2026Journal Article
A rRNA hybridization-based approach for rapid and accurate identification of diverse fungal pathogens.
Elizabeth A Yee1, Brooks J Burt2, Poppy C S Sephton-Clark2,3, M Lauren Donnelly-Morell1,4, Aidan Z Wang1, Isaac H Solomon5, Evan Mojica6, Christina A Cuomo1,7, Roby P Bhattacharyya1,8
1Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge MA 02142 USA.
2Genomic Center for Infectious Disease, Broad Institute of MIT and Harvard, Cambridge MA 02142 USA.
3Present address: Valo Health, 75 Hayden Avenue Suite 200, Lexington, MA 02421 USA.
4Department of Pathology, Massachusetts General Brigham, Harvard Medical School, Boston, MA USA.
5Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 USA.
6Microbiology Laboratory, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
7Department of Molecular Microbiology and Immunology, Brown University, Providence RI 02912 USA.
8Infectious Diseases Division, Department of Medicine, Massachusetts General Hospital, Boston MA 02114 USA.
Abstract
Invasive fungal infections are a global threat for which early diagnosis is critical for patient outcomes, but current diagnostic measures remain notoriously slow. Here we extend our multiplexed, hybridization-based rRNA-targeted strategy for rapid, sensitive pathogen identification, previously designed for diverse bacteria and Candida species, to identify diverse fungal pathogens. We created a se…
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