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Peer-Reviewed Publication
Eur J Pharm Sci2026;107642.August 15, 2026Journal Article

Sustained Drug Exposure Drives Efficacy in Mice: PK/PD Analysis of Corallopyronin A against Wolbachia using Physiologically Based Absorption Modeling.

J Heitkötter1, F Risch2, A Schiefer3, K Pfarr4, M P Hübner5, S Kehraus6, A Hoerauf7, X Pepin8, K G Wagner9
1Department of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, Gerhard-Domagk-Str. 3, 53121 Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Germany. Electronic address: j.heitkoetter@uni-bonn.de.
2University of Bonn, University Hospital Bonn, Institute for Medical Microbiology, Immunology and Parasitology, Venusberg - Campus 1, 53127 Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Germany. Electronic address: frederic.risch@ukbonn.de.
3University of Bonn, University Hospital Bonn, Institute for Medical Microbiology, Immunology and Parasitology, Venusberg - Campus 1, 53127 Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Germany. Electronic address: andrea.schiefer@uni-bonn.de.
4University of Bonn, University Hospital Bonn, Institute for Medical Microbiology, Immunology and Parasitology, Venusberg - Campus 1, 53127 Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Germany. Electronic address: kenneth.pfarr@ukbonn.de.
5University of Bonn, University Hospital Bonn, Institute for Medical Microbiology, Immunology and Parasitology, Venusberg - Campus 1, 53127 Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Germany. Electronic address: huebner@uni-bonn.de.
6Institute of Pharmaceutical Biology, University of Bonn, Nußallee 6, 53115 Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Germany. Electronic address: skehraus@uni-bonn.de.
7University of Bonn, University Hospital Bonn, Institute for Medical Microbiology, Immunology and Parasitology, Venusberg - Campus 1, 53127 Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Germany. Electronic address: hoerauf@uni-bonn.de.
8PBPK Research and Development, Simulations Plus, Inc., Research Triangle Park, NC 27709, USA. Electronic address: xavier.pepin@simulations-plus.com.
9Department of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, Gerhard-Domagk-Str. 3, 53121 Bonn, Germany; German Center for Infection Research (DZIF), partner site Bonn-Cologne, Germany. Electronic address: karl.wagner@uni-bonn.de.
PubMed DOI

Abstract

Corallopyronin A (CorA) depletes essential Wolbachia endosymbionts of filarial nematodes and is therefore a promising candidate for treating the neglected tropical diseases lymphatic filariasis and onchocerciasis. To optimize anti-Wolbachia therapy, the pharmacokinetic/pharmacodynamic (PK/PD) relationship was investigated. Due to the intra-nematode and -cellular target, conventional minimal inhibi…

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