Health AI Central
Peer-Reviewed Publication
Nat Med2026August 14, 2026Journal Article

Histological aging signatures for monitoring tissue-specific aging and disease.

Ernesto Abila1,2, Iva Buljan1,2, Yimin Zheng1, Lisa Kleissl1,3, Sigrid Klotz4, Tamas Veres1, Zhilong Weng5, Maja Nackenhorst6, Rizqah Kamies7,8, Anja Michl7,8, Safwen Kadri7,8, Samir Moustafa1,9, Wolfgang Hulla10, Matthias Perkonigg11, Mathias Drach3, Philipp Tschandl3, Barbara Sterniczky3, Matthias Heinig12,13,14, Laurens J De Sadeleer15, Wim Wuyts15, Bart Vanaudenaerde15, Laurens J Ceulemans15,16, Daniel D Buchanan17,18,19, Lochlan J Fennell20, Georg Stary1,3, Yuri Tolkach5, Adelheid Wöhrer4,11, Herbert B Schiller7,8,21, André F Rendeiro22,23
1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
2Ludwig Boltzmann Institute for Network Medicine, University of Vienna, Vienna, Austria.
3Department of Dermatology, Medical University of Vienna, Vienna, Austria.
4Department of Neurology, Division of Neuropathology and Neurochemistry, Medical University of Vienna, Vienna, Austria.
5Institute of Pathology, University Hospital of Cologne, Medical Faculty, University of Cologne, Cologne, Germany.
6Department of Pathology, Medical University of Vienna, Vienna, Austria.
7Research Unit Precision Regenerative Medicine, Helmholz Munich, Munich, Germany.
8Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany.
9Faculty of Computer Science, University of Vienna, Vienna, Austria.
10Institute of Pathology, Landesklinikum Wiener Neustadt, Wiener Neustadt, Austria.
11Institute of Neuropathology and Neuromolecular Pathology, Medical University of Innsbruck, Innsbruck, Austria.
12Institute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.
13Department of Computer Science, TUM School of Computation, Information and Technology, Technical University of Munich, Garching, Germany.
14German Centre for Cardiovascular Research (DZHK), Munich Heart Association, Partner Site Munich, Berlin, Germany.
15Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
16Department of Thoracic Surgery, UZ Leuven, Leuven, Belgium.
17Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia.
18Collaborative Centre for Genomic Cancer Medicine, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.
19Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.
20Centre for Bionnovation and the School of Health, University of Sunshine Coast, Sippy Downs, Queensland, Australia.
21Institute of Experimental Pneumology, LMU University Hospital, Ludwig-Maximilians University, Munich, Germany.
22CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. arendeiro@cemm.oeaw.ac.at.
23Ludwig Boltzmann Institute for Network Medicine, University of Vienna, Vienna, Austria. arendeiro@cemm.oeaw.ac.at.
PubMed DOI

Abstract

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types across 983 individuals in the Genotype-Tissue Expression cohort. By leveraging deep learning, we quantified nuanced morpholo…

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