Health AI Central
Peer-Reviewed Publication
Oxid Med Cell Longev2026;2026(1):e9948225.January 1, 2026Journal Article

Modelling Ferroptosis in a Human Microglial Line by Sequential Exposure to Iron and GPX4 Inhibition.

Renaud Bussiere1, Nikhil Tulsian2, Cecilia Wieder1, Dewi McConnaughie1, Evie Tynan1, Andrew Lowe1, Esther Cheow2, Matthew Choo2, Jill C Richardson1, James A Duce1, Sébastien Gillotin1,3
1R&D Innovation Centre, MSD, 120 Moorgate, EC2M 6UR, London, UK.
2Quantitative Biosciences, MSD International GmBH (Singapore Branch), Singapore, Singapore.
3Aqemia, 29-31 Euston Road, NW1 2SD, London, UK.
PubMed PMC DOI PDF

Abstract

Excessive iron accumulation is a pathological feature of several neurodegenerative diseases (NDDs), and a growing body of evidence suggests that ferroptosis, an iron-dependent form of regulated cell death (RCD) driven by lipid peroxidation, is implicated in their pathogenesis. Microglia, the brain's resident immune cells, buffer iron overload but become susceptible to ferroptotic death, exacerbati…

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