Health AI Central
Peer-Reviewed Publication
J Mol Cell Cardiol2026August 10, 2026Journal Article

Computational models show that functional remodeling, not anatomy, reshapes physiological determinants of cardiac performance in hypertrophic cardiomyopathy.

Cristobal Rodero1, Lara Curran2, Christopher W Lanyon3, Paolo Inglese4, Abdul Qayyum5, Rosie K Barrows6, Jose A Solis-Lemus5, Shahrokh Rahmani5, Marina Strocchi7, Angela W C Lee5, Tiffany M G Baptiste6, Ludovica Cicci5, Edward Burford8, Elias Karabelas9, Christoph M Augustin10, Gernot Plank11, Richard D Wilkinson3, Antonio de Marvao12, James S Ware2, Declan P O'Regan4, Sanjay K Prasad13, Steven A Niederer14
1National Heart and Lung Institute (NHLI), Imperial College London, London, UK. Electronic address: cristobal.rodero@imperial.ac.uk.
2National Heart and Lung Institute (NHLI), Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.
3School of Mathematical Sciences, University of Nottingham, Nottingham, UK.
4Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.
5National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
6Biomedical Engineering Department, King's College London, London, UK; National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
7National Heart and Lung Institute (NHLI), Imperial College London, London, UK; Cardiac Rhythm Management, Medtronic, London, UK.
8British Heart Foundation Centre of Research Excellence, School of Cardiovascular & Metabolic Medicine and Sciences, King's College London, London, UK.
9Institute for Mathematics and Scientific Computing, University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria; NumeriCor GmbH, Graz, Austria.
10Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
11Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria.
12Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK; Department of Women and Children's Health, King's College London, London, UK; British Heart Foundation Centre of Research Excellence, School of Cardiovascular & Metabolic Medicine and Sciences, King's College London, London, UK.
13National Heart and Lung Institute (NHLI), Imperial College London, London, UK; Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
14National Heart and Lung Institute (NHLI), Imperial College London, London, UK; The Alan Turing Institute, London, UK.
PubMed DOI

Abstract

Hypertrophic cardiomyopathy (HCM) is a condition characterized by variable patterns of myocardial hypertrophy. Progressive functional remodeling of material properties contributes to symptoms, disease progression, and variability in treatment response. However, it is not clear how these properties interact to determine cardiac performance and response to treatment. We quantified how cardiac anatom…

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