Peer-Reviewed Publication
Drug Alcohol Depend2026;286113276.July 29, 2026Journal Article
Prediction of alcohol consumption: The role of genetics, impulsivity, and sensation seeking from adolescence to adulthood.
Lilia G Geel1, Robin P Corley2, Chandra A Reynolds3, Sandra Sanchez-Roige4, 5, Soo H Rhee3, Daniel E Gustavson3
1Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. Electronic address: lilia.geel@colorado.edu.
2Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
3Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
4Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
523andMe Research Institute, Palo Alto, CA 94306, USA.
Abstract
BACKGROUND: There are well-known phenotypic and genetic associations among impulsivity, sensation seeking (SS), and alcohol consumption, but whether they vary between adolescence and early adulthood remains unclear.
PURPOSE/HYPOTHESES: We hypothesized that adolescent alcohol consumption would be better predicted by polygenic indices (PGIs) of impulsivity and SS than PGIs of adult alcohol consumpt…
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