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Peer-Reviewed Publication
J Neurol2026;273(8)August 3, 2026Journal Article

Personality change after traumatic brain injury: a systematic review and meta-analysis.

Lauren Burns1, Kelly Jones2, Keishema Kerr1, Nora Brennan3, Natalie Clapshaw3, Huw Green4, Hannah Farrimond5, Claire Stone3, Sam Wilkinson5, Members Of Headway London3, Vaughan Bell6,7
1Clinical, Educational and Health Psychology, University College London, London, UK.
2University of Swansea, Swansea, UK.
3Headway London, London, UK.
4Department of Neuropsychology, Addenbrooke's Hospital, Cambridge, UK.
5Department of Social and Political Sciences, Philosophy, and Anthropology, University of Exeter, Exeter, UK.
6Clinical, Educational and Health Psychology, University College London, London, UK. vaughan.bell@ucl.ac.uk.
7Dept of Neuropsychiatry, South London and Maudsley NHS Foundation Trust, London, UK. vaughan.bell@ucl.ac.uk.

Abstract

BACKGROUND: Personality change is a debilitating consequence of traumatic brain injury (TBI), yet its prevalence, characteristics, and treatment remain poorly understood. METHODS: We completed a pre-registered (CRD42023440990) systematic review and meta-analysis searching four databases (MEDLINE, PsycINFO, EMBASE and CINAHL) for primary studies assessing personality change after TBI. We synthesiz…

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