Peer-Reviewed Publication
Res Sq2026July 14, 2026Journal Article
Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptides.
Rebecca Elyanow1, Amanda J Moore1, Tim Hayes1, Enrique Crespo1, Erica L Gumucio1, Melanie Laur1, Sami Rantisi1, Ninnia Lescano1, Brad Greenfield1, Patrick Monnahan1, Brian C Zhang1, Rebecca B Harris1, Edward J Osborne1, Ryan Brown1, Krystin Samms1, Joanna Maltbaek1, Alex Dahmani1, Todd M Brusko2, Aaron Michels3, Mikael Knip4,5, Sharon Benzeno1, Bryan Howie1, Mark Klinger1, Harlan Robins1
1Adaptive Biotechnologies, Seattle, WA, USA.
2Department of Pathology, Immunology, and Laboratory Medicine, Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL, USA.
3Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.
4Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.
5Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Abstract
While recent studies have revealed much about the pathogenesis of type 1 diabetes (T1D), the self-antigens and immune receptors that drive cellular autoimmunity have not been precisely determined. In this study, we identify disease-associated T-cell receptor (TCR) sequences, provide evidence that they are involved in T1D pathogenesis, and connect them to specific antigens implicated in beta-cell a…
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