Radiation dose reduction in computed tomography perfusion of acute ischemic stroke patients using a denoising autoencoder.

Pattarawut Charatpangoon¹, Pauline Delannoy², Fernando Vega³, Rory Gilliland⁴, Abdoljalil Addeh⁵, Muhammad Mahajna⁶, Raneem Sheronick⁷, Connor McDougall⁸, Ting-Yim Lee⁹, Philip A Barber⁸, Bijoy K Menon⁸, Aravind Ganesh⁸, M Ethan MacDonald¹⁰

¹Department of Clinical Neurosciences, University of Calgary, Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.

²Department of Clinical Support, Olea Medical, La Ciotat, France.

³Radiology Department, Universitair Medisch Centrum Groningen, Groningen, the Netherlands.

⁴Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Canada.

⁵Department of Mathematics and Computing, Mount Royal University, Calgary, Canada.

⁶Department of Biomedical Engineering, University of Calgary, Calgary, Canada.

⁷Department of Oncology, University of Calgary, Calgary, Canada.

⁸Department of Clinical Neurosciences, University of Calgary, Calgary, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada; Department of Radiology, University of Calgary, Calgary, Canada.

⁹Lawson Health Research Institute, Western University, Ontario, Canada.

¹⁰Hotchkiss Brain Institute, University of Calgary, Calgary, Canada; Department of Biomedical Engineering, University of Calgary, Calgary, Canada; Department of Radiology, University of Calgary, Calgary, Canada; Department of Electrical & Software Engineering, University of Calgary, Calgary, Canada. Electronic address: ethan.macdonald@ucalgary.ca.

PubMed DOI

Abstract

BACKGROUND: Ischemic stroke results from the occlusion of a cerebral artery and is a leading cause of mortality and disability worldwide. Multimodal computed tomography (CT), including CT perfusion (CTP) and CT angiography, is crucial to acute stroke evaluation but involves higher radiation exposure than non-contrast CT due to repeated volumetric imaging. Reducing CTP radiation dose without losing…

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