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Peer-Reviewed Publication
Eur Respir J2026July 23, 2026Letter

AI-driven CT quantification of mucus plugs to evaluate the effect of inhaled hypertonic saline in children aged 3-6 years with CF: a randomized controlled trial.

Yuxin Chen1,2, Rudolfs Latisenko3, Stephanie D Davis4, Margaret Rosenfeld5, Felix Ratjen6, Karen D Hinckley Stukovsky7, Stephen Stick8, Harm A W M Tiddens2,4,
1Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China y.chen.1@erasmusmc.nl.
2Department of Paediatric, Division of Respiratory Medicine and Allergology, Sophia Children's Hospital, Erasmus MC, Rotterdam, Netherlands.
3Thirona, Nijmegen, Netherlands.
4Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
5Seattle Children's Research Institute, Seattle, WA, United States.
6Division of Respiratory Medicine, Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada.
7Collaborative Health Studies Coordinating Center, the University of Washington, Seattle, United States.
8Wal-yan Respiratory Research Centre, Telethon Kids Institute, Perth, Australia.
PubMed DOI

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