Health AI Central
Peer-Reviewed Publication
Neuroimage2026;338122137.September 1, 2026Journal Article

Self-supervised spectral-temporal denoising for dynamic deuterium metabolic imaging.

Hauke Fischer1, Stanislav Motyka2, Anna Duguid3, Fabian Niess3, Bernhard Strasser3, Viola Bader3, Sabina Frese3, Sara Huskic4, Georg Widhalm5, Sumit Kaushik6, Aaron P Osburg7, Wolfgang Bogner2
1High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria; Comprehensive Center for AI in Medicine (CAIM), Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria. Electronic address: hauke.fischer@meduniwien.ac.at.
2High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria; Comprehensive Center for AI in Medicine (CAIM), Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria; Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria.
3High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria.
4High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria; Department of Neurosurgery, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria.
5Department of Neurosurgery, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria.
6High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria; Department of Radiology and Nuclear Medicine, St. Olav's University Hospital, Trondheim, Norway; Department of Cybernetics and Biomedical Engineering, VSB-Technical University of Ostrava, Ostrava-Poruba, Czech Republic.
7High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria; Comprehensive Center for AI in Medicine (CAIM), Medical University of Vienna, Lazarettgasse 14, Vienna, 1090, Austria.
PubMed DOI

Abstract

Dynamic deuterium metabolic imaging (DMI) enables time-resolved mapping of cerebral glucose metabolism in vivo, yet its intrinsically low SNR often renders voxel-wise metabolite quantification unstable-particularly at early repetitions. Low-rank denoising is widely used in MR spectroscopic imaging (MRSI)/DMI to improve robustness, but very low-SNR regimes and dynamic studies remain challenging. Se…

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