Peer-Reviewed Publication
Colloids Surf B Biointerfaces2026;268(Pt 1):115983.December 1, 2026Journal Article
Hybrid ZnFe2O4nanozyme for ultrasound-activated multi-radical synergistic tumor immunotherapy and magnetic resonance imaging.
Di Zhang1, Ao Sun1, Zhan Xiao2, Zhenyu Liu1, Zhenmeng Sun3, Lingbo Zhang4, Guoyi Lv5, Dongdong Jiang6
1Department of Radiology, Wuhan Fourth Hospital, Wuhan, Hubei 430033, China.
2Health Science Center, Yangtze University, Jingzhou 434000, China.
3Siemens Healthineers Digital Technology (Shanghai) Co., Ltd., Guangzhou, Wuhan, Hubei 430030, China.
4Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: lbzhang@tjh.tjmu.edu.cn.
5Department of Radiology, Wuhan Fourth Hospital, Wuhan, Hubei 430033, China. Electronic address: laodongdong999@sina.com.
6Department of Radiology, Wuhan Fourth Hospital, Wuhan, Hubei 430033, China. Electronic address: jiang.1993@163.com.
Abstract
Ultrasound (US)-mediated sonodynamic therapy (SDT) that generates reactive oxygen species (ROS) has been extensively explored for tumor treatment due to its non-invasiveness and deep tissue ablation ability. Nevertheless, the therapeutic efficacy of single ROS-based SDT is severely restricted by the immunosuppressive tumor microenvironment (TME). In this study, we designed and synthesized a core-s…
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