Granulomatous inflammation in lung and lymph node specimens: A molecularly enhanced pathology-based algorithm for etiologic differential diagnosis.

Min Hong¹, Lupeng Ji¹, Jiong Gao², Hui Zhang³, Shun Ge⁴, Chao Yuan⁵

¹The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.

²Hangzhou Adicon Clinical Laboratories Co., Ltd., West Lake District, Hangzhou, China. Electronic address: jiong.gao01@adicon.com.cn.

³Hangzhou Adicon Clinical Laboratories Co., Ltd., West Lake District, Hangzhou, China; Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen, China. Electronic address: zhanghui_i@mindray.com.

⁴Hangzhou Adicon Clinical Laboratories Co., Ltd., West Lake District, Hangzhou, China. Electronic address: shun.ge@adicon.com.cn.

⁵Hangzhou Adicon Clinical Laboratories Co., Ltd., West Lake District, Hangzhou, China. Electronic address: 13456299385@163.com.

PubMed DOI

Abstract

Granulomatous inflammation is frequently encountered in lung and lymph node specimens and represents a diagnostic challenge because diverse infectious, immune-mediated, exposure-related, and neoplastic conditions may produce overlapping histologic patterns. Necrotizing, non-necrotizing, suppurative, foreign body-type, vasculitic, and malignancy-associated granulomas provide important diagnostic cl…

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