Health AI Central
Peer-Reviewed Publication
Abdom Radiol (NY)2026July 13, 2026Journal Article

Machine learning modeling to predict HCC locations in cirrhotic patients undergoing MRI - a proof-of-concept study.

Olivia Gaddum1,2, Tal Zeevi1, Weicheng Dai1, MingDe Lin1,3, Shawn Thomas1,4, Jonathan Tefera1, Rabea Sobirey1,2, Nickolai Joel Matuschewski1,2, Moritz Gross1,2, Sara A Abosabie1,2, Salma A S Abosabie1,2,5,6, Bernhard Gebauer2, Lynn Jeanette Savic2,7,8,9, David C Madoff1, James S Duncan1,10, Julius Chapiro11
1Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.
2Department of Radiology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität, Berlin, Germany.
3Visage Imaging Inc., California, San Diego, USA.
4Department of Radiology, University of California, San Diego, USA.
5Rudolf Virchow Center for Integrative and Translational Biomedicine, Julius Maximilians University of Wuerzburg, Wuerzburg, Germany.
6Institute of Experimental Biomedicine, University Hospital Wuerzburg, Wuerzburg, Germany.
7Experimental Clinical Research Center (ECRC), Charité-Universitätsmedizin Berlin and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin, Germany.
8Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.
9Department of Radiology and Nuclear Medicine, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
10Biomedical Engineering, Radiology & Biomedical Imaging, Electrical Engineering and Statistics & Data Science, Yale University, Connecticut, New Haven, USA.
11Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA. julius.chapiro@yale.edu.
PubMed DOI

Abstract

PURPOSE: Current hepatocellular carcinoma (HCC) surveillance guidelines rely on manually defined LI-RADS (Liver Imaging Reporting and Data System) features rather than imaging data analysis. This study evaluates the feasibility of machine-learning (ML)-based image analysis frameworks to identify and localize hepatic parenchyma at elevated risk for HCC. METHODS: In this retrospective study, cirrho…

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