A system capable of verifiably and privately screening global DNA synthesis.

Carsten Baum^1,2, Jens Berlips³, Walther Chen³, Helena Cozzarini³, Hongrui Cui⁴, Ivan Damgård¹, Jiangbin Dong⁵, Kevin M Esvelt^3,6, Leonard Foner³, Mingyu Gao^5,7, Dana Gretton^3,6, Martin Kysel³, Juanru Li⁴, Xiang Li⁵, Omer Paneth⁸, Ronald L Rivest⁸, Francesca Sage-Ling³, Adi Shamir⁹, Yue Shen¹⁰, Meicen Sun¹¹, Vinod Vaikuntanathan⁸, Lynn Van Hauwe³, Theia Vogel³, Benjamin Weinstein-Raun³, Yun Wang¹⁰, Daniel Wichs¹², Stephen Wooster³, Andrew C Yao^3,5,7, Yu Yu^4,7, Haoling Zhang¹⁰, Kaiyi Zhang⁴

¹Department of Computer Science, Aarhus University, Aarhus Centrum 8000, Denmark.

²DTU Compute, Technical University of Denmark, Kongens Lyngby 2800, Denmark.

³SecureDNA Foundation, Basel 4010, Switzerland.

⁴Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

⁵Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084, China.

⁶Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

⁷Shanghai Qi Zhi Institute, Shanghai 200232, China.

⁸Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

⁹Department of Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel.

¹⁰BGI Research, Changzhou 213299, China.

¹¹Department of Political Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

¹²Department of Computer Science, Northeastern University, Boston, MA 02115, USA.

PubMed PMC DOI PDF

Abstract

Printing custom DNA sequences is essential to scientific and biomedical research, but the technology can be used to manufacture plagues as well as cures. Just as ink printers recognize and reject attempts to counterfeit money, DNA synthesizers and assemblers should deny unauthorized requests to make viral DNA that could be misused. There are three complications. First, we do not need to quickly up…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free Account Sign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.