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Peer-Reviewed Publication
PLoS One2026;21(7):e0351477.January 1, 2026Journal Article

Multimodal imaging to analyze the biomechanical properties of kidney tumors, evaluating feasibility, inter-modality correspondence, and diagnostic value (UroCCR-115).

Mattia Ronca1,2, Paolo Conforti1,2, Amandine Crombé3,4, Manon Jaffredo1,2, Solène Ricard1,2, Thierry Colin5, Mokrane Yacoub6, Yann Le Bras3, Jean-Christophe Bernhard1,2, Gaelle Margue1,2, Eva Fourage-Jambon2,3
1Urology Department, Bordeaux University Hospital, Bordeaux, France.
2I, CaRe Bordeaux-BRIC Inserm U1312, Bordeaux, France.
3Service d'imagerie Médicale Adulte, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
4Sarcotarget -BRIC Inserm U1312, Bordeaux, France.
5SOPHiA GENETICS, Multimodal R&D Team, Pessac, France.
6Department of Pathology, Bordeaux University Hospital, Bordeaux, France.

Abstract

INTRODUCTION: Assessment of renal tissue and renal tumor stiffness may provide complementary information for tissue characterization; however, conventional imaging modalities such as multiphasic computed tomography (CT) do not directly quantify biomechanical properties. Elastography techniques, including magnetic resonance elastography (MRE) and ultrasound elastography (US-E), allow noninvasive me…

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