Peer-Reviewed Publication
J Appl Clin Med Phys2026;27(7):e70696.July 1, 2026Journal Article
An integrated toolkit for structure generation, optimization, and evaluation in spatially fractionated radiation therapy.
Japan K Patel1, Anthony Magliari2, Gregory Gill3, Todd A Wareing2, Tenzin Kunkyab4, Caleb Raman5, Ilias Sachpazidis6, Peter Szentivanyi2, Ryan Clark2, Pierre Lansonneur2, Arjun Karnwal7, Michael Kudla8, Sergejs Unterkirhers9, Junqi Song10, Jun Yang10, Matthew C Schmidt1,11
1Gateway Scripts, Saint Louis, Missouri, USA.
2Medical Affairs, Varian Medical Systems, Palo Alto, California, USA.
3Department of Radiation Oncology, Intermountain Health, Salt Lake City, Utah, USA.
4Department of Radiation Oncology, Icahn School of Medicine at Mt. Sinai, New York City, New York, USA.
5Biological Sciences Division, University of Chicago, Chicago, Illinois, USA.
6Department of Radiation Oncology, University of Freiburg, Freiburg, Baden-Württemberg, Germany.
7Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.
8Radiation Therapy Program, BC Cancer, Vancouver, British Columbia, Canada.
9Clinic Hirslanden, Zurich, Zurich, Switzerland.
10Foshan Fosun Chancheng Hospital, Foshan City, Guangdong, China.
11School of Medicine, Washington University, St. Louis, Missouri, USA.
Abstract
PURPOSE: Spatially fractionated radiation therapy (SFRT) planning requires three coordinated tasks: generation of high-dose sphere structures, position-aware optimization, and peak-valley dose ratio evaluation. In practice, clinicians and researchers address these tasks with a combination of closed-source scripts, research codes, and manual calculation. The absence of a unified, commercially deplo…
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