Impact of obesity and type 2 diabetes on muscle power, quality, and force-velocity, and their relation to functional capacity.

Anders Stouge^1,2,3,4, Anders Hammer Nielsen-Kudsk^1,2, Michael Vaeggemose^3,5, Hatice Tankisi^4,6, Jens Meldgaard Bruun^2,4, Henning Andersen^1,4

¹Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.

²Steno Diabetes Center Aarhus, Aarhus, Denmark.

³The MR Research Centre, Aarhus University, Aarhus, Denmark.

⁴Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

⁵GE HealthCare, Brøndby, Denmark.

⁶Department of Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Obesity and type 2 diabetes (T2D) increase the risk of sarcopenia and mobility decline, yet the underlying muscle contractile alterations remain poorly understood. This study investigated how severe obesity and T2D affect muscle power, force-velocity relationships, and muscle quality. METHODS: In this cross-sectional study, 45 middle-aged individuals were categorized as non-obesity (N…

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