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Peer-Reviewed Publication
Am J Prev Cardiol2026;29101656.October 1, 2026Journal Article

Comparing incidence of heart failure in individuals with enlarged cardiac chambers versus diabetes.

Seyed Reza Mirjalili1, Kyle Atlas1, Anthony P Reeves2, Chenyu Zhang1, Jakob Wasserthal3, Amir Azimi1, Ali Hashemi1, Mohammadhossein Mozafarybazargany1, Amir Ghaffari Jolfayi1, Thomas Atlas4, Claudia I Henschke5, David F Yankelevitz5, Javier J Zulueta5, Jeffrey Mechanick6, Andrea D Branch5, Ning Ma5, Rowena Yip5, Wenjun Fan7, Sion K Roy8, Khurram Nasir9, Sabee Molloi10, Zahi Fayad5, Michael V McConnell11, Ioannis A Kakadiaris12, George Abela13, Rozemarijn Vliegenthart14, David J Maron11, Jagat Narula15, Kim A Williams16, Prediman K Shah17, Matthew J Budoff8, Daniel Levy18, Roxana Mehran5, Robert A Kloner19,20, Nathan D Wong21, Morteza Naghavi1
1HeartLung.AI, Houston, TX 77021, USA.
2Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.
3University of Basel, Switzerland, Basel 4001, Switzerland.
4Tustin Teleradiology, Tustin, CA 92780, USA.
5Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
6Kravis Center for Clinical Cardiovascular Health, Mount Sinai Fuster Heart Hospital, New York, NY 10029, USA.
7Department of Epidemiology and Biostatistics, Wen School of Public Health, University of California, Irvine, USA.
8The Lundquist Institute, CA 90502, USA.
9Houston Methodist Hospital, Houston, TX 77030, USA.
10Department of Radiology, University of California Irvine, CA 92697, USA.
11Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
12Computational Biomedicine Laboratory, Department of Computer Science, University of Houston, Houston, TX, USA.
13Division of Cardiology, Michigan State University, East Lansing, MI 48823, USA.
14Dept of Radiology, University Medical Center Groningen, GZ 9713, the Netherlands.
15University of Houston, Houston, TX 77030, USA.
16University of Louisville, Louisville, KY 40292, USA.
17Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
18Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20824, USA.
19Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
20Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
21Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, University of California Irvine, CA 92697, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Opportunistic cardiac chamber volumetry derived from coronary artery calcium (CAC) scans using the AI-CVD platform predicts heart failure (HF) independent of conventional risk factors. Type 2 diabetes mellitus (T2DM), which classifies individuals as Stage A HF, is associated with chamber enlargement; however, the HF risk associated with chamber enlargement in the absence of T2DM has no…

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