Peer-Reviewed Publication
Radiol Cardiothorac Imaging2026;8(4):e250214.August 1, 2026Journal Article
AI-quantified Myosteatosis at CAC CT for Prediction of Atrial Fibrillation and Heart Failure: The Multi-Ethnic Study of Atherosclerosis.
Amir Azimi1, Kyle Atlas1, Anthony P Reeves2, Chenyu Zhang1, Jakob Wasserthal3, Seyed Reza Mirjalili1, Thomas Atlas4, Claudia I Henschke5, David F Yankelevitz5, Javier J Zulueta5, Jeffrey I Mechanick6, Andrea Branch5, Ning Ma5, Rowena Yip5, Wenjun Fan7, Sion K Roy8, Khurram Nasir9, Sabee Molloi7, Zahi A Fayad5, Michael V McConnell10, Ioannis A Kakadiaris11, George S Abela12, Rozemarijn Vliegenthart13, David J Maron9, Jagat Narula11, Kim A Williams14, Prediman K Shah15, Matthew J Budoff8, Daniel Levy16, Emelia J Benjamin17, Nathan D Wong18, Morteza Naghavi1
1HeartLung.AI, 2450 Holcombe Blvd, Houston, TX 77021.
2Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY.
3University of Basel, Basel, Switzerland.
4Tustin Teleradiology, Tustin, Calif.
5Icahn School of Medicine at Mount Sinai, New York, NY.
6Kravis Center for Clinical Cardiovascular Health, Mount Sinai Fuster Heart Hospital, New York, NY.
7Department of Radiology, University of California, Irvine, Calif.
8The Lundquist Institute, Torrance, Calif.
9Houston Methodist Hospital, Houston, Tex.
10Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, Calif.
11University of Houston, Houston, Tex.
12Division of Cardiology, Michigan State University, East Lansing, Mich.
13University Medical Center Groningen, Groningen, the Netherlands.
14University of Louisville, Louisville, Ky.
15Cedars-Sinai Medical Center, Los Angeles, Calif.
16Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
17School of Public Health, Boston University, Boston, Mass.
18Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, University of California, Irvine, Calif.
Abstract
Purpose To evaluate whether the artificial intelligence (AI)-quantified mean thoracic skeletal muscle (TSM) attenuation from coronary artery calcium (CAC) scans predicts incident cardiovascular disease (CVD), with a focus on atrial fibrillation (AF) and heart failure (HF). Materials and Methods Data from the Multi-Ethnic Study of Atherosclerosis, including participants without baseline CVD who und…
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