Intrinsic excitation-inhibition imbalance in major depressive disorder.

Yao Ge¹, Lijuan Chen¹, Yu Shen¹, Ninghua Li¹, Bo Liu¹, Xiaojuan Lv¹, Yan Bai¹, Wei Wei¹, Yaping Wu¹, Kaixin Li², Mengzhu Wang², Meiyun Wang³

¹Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Zhengzhou, China.

²MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China.

³Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Zhengzhou, China; Biomedical Research Institute, Henan Academy of Sciences, Zhengzhou, China. Electronic address: mywang@zzu.edu.cn.

PubMed DOI

Abstract

BACKGROUND: Major depressive disorder (MDD) ranks among the foremost contributors to disability worldwide, yet its neurophysiological mechanisms remain poorly understood. Excitation-inhibition (E/I) imbalance has been implicated in MDD pathophysiology, but cortex-wide E/I ratio and its molecular substrates in MDD remain unknown. METHODS: Resting-state functional magnetic resonance imaging data fr…

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