Incremental diagnostic value of microstructural time-dependent diffusion MRI in differentiating PCNSL from glioblastoma over conventional MRI.

Chunjie Wang¹, Yan Xie¹, Xiaojing Liang¹, Yonggui Fu¹, Chen Zhang², Feiweier Thorsten³, Meining Chen², Jianguo Liu⁴, Qingjun Wang⁵

¹Department of Radiology, The 6(th) Medical Center, Chinese PLA General Hospital, Beijing, China.

²Department of MR Research Collaboration, The Siemens Healthineers, Beijing, China.

³Department of MR Research and Clinical Translation, The Siemens Healthineers AG, Erlangen, Germany.

⁴Department of Neurology, The 6(th) Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address: doctorljg@sina.com.

⁵Department of Radiology, The 6(th) Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address: wangqingjun@301hospital.com.cn.

PubMed DOI

Abstract

PURPOSE: To evaluate the incremental diagnostic value of microstructural parameters derived from time-dependent diffusion MRI (td-dMRI) over conventional MRI in differentiating primary central nervous system lymphomas (PCNSLs) from glioblastomas (GBMs). MATERIALS AND METHODS: This study included 63 patients with PCNSL and 98 with GBM who underwent preoperative conventional MRI and td-dMRI. Quanti…

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