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Peer-Reviewed Publication
J Clin Med2026;15(12)June 19, 2026Journal Article

Waist Circumference Modifies the Association Between a Deep Learning-Derived Retinal Biomarker and Coronary Artery Calcium Score in Asymptomatic Adults.

Sung-Hoon Jung1, Sung-Goo Kang2, Sang-Wook Song2, Se-Hong Kim2, Dongjin Nam3, Junseung Rho2
1Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea.
2Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 16247, Republic of Korea.
3Mediwhale Inc., Seoul 06049, Republic of Korea.

Abstract

Background: The deep learning-derived retinal cardiovascular risk index (Reti-CVD) is a deep learning-derived retinal biomarker calculated from non-mydriatic fundus photographs for cardiovascular risk assessment. This study examined whether obesity phenotype, particularly central adiposity, modifies the association between Reti-CVD and coronary artery calcium score (CACS) in asymptomatic adults un…

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