Peer-Reviewed Publication
Sci Rep2026;16(1)June 22, 2026Journal Article
Associations between fat distribution and obstructive sleep apnea severity among individuals with type 2 diabetes: an MRI-based study.
Kim Ahtola1, Martin Ulander2,3, Jonas Agholme1, Farida Amiri1, Pontus Henriksson1, Olof Dahlqvist Leinhard1,4, Peter Lundberg5,6,7, Nils Dahlström1,5, Carl-Johan Carlhäll5,8, Stergios Kechagias9, Patrik Nasr5,10,9, Mikael Forsgren1,5,4, Mattias Ekstedt5,9, Fredrik Iredahl11,12
1Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
2Department of Biomedical and Clinical Sciences, Division of Neurobiology, Faculty of Medicine, Linköping University, Linköping, Sweden.
3Department of Clinical Neurophysiology, Linköping University Hospital, Linköping, Sweden.
4AMRA Medical AB, Linköping, Sweden.
5Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
6Department of Radiation Physics, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
7Department of Radiology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
8Department of Clinical Physiology in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
9Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
10Wallenberg Center for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden.
11Primary Health Care Center Åby, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden. fredrik.iredahl@liu.se.
12Wallenberg Center for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden. fredrik.iredahl@liu.se.
Abstract
Obstructive Sleep Apnea (OSA) affects 1 billion people globally, with a male-to-female ratio of 2:1. While obesity is a major risk factor, sex differences in fat distribution may influence OSA risk. This study examined the relationship between visceral (VAT), subcutaneous (ASAT), and total abdominal fat (TAAT) and OSA severity in patients with type 2 diabetes (T2DM). We enrolled 164 T2DM patients…
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