Corticospinal tract risk modifies motor recovery after minimally invasive surgery for intracerebral hemorrhage: a secondary analysis of MISTIE-III.

Olivia N Murray^1,2, David A Jenkins³, Nathan Walborn⁴, Hiren C Patel⁵, George Harston^6,7, Timothy Cootes³, Catharina Jm Klijn⁸, Wendy Ziai⁹, Daniel F Hanley^4,10, Ulrike Hammerbeck¹¹, Adrian R Parry-Jones^1,2

¹Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

²Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust & University of Manchester, Manchester, UK.

³Division of Informatics, Imaging and Data Science, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

⁴Brain Injury Outcomes, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

⁵Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Manchester, UK.

⁶Brainomix, Oxford, UK.

⁷Acute Stroke Programme, Oxford University Hospitals NHSFT, Oxford, UK.

⁸Department of Neurology, Radboud University Medical Center, Nijmegen, Netherlands.

⁹The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

¹⁰Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

¹¹Centre of Human and Applied Physiological Sciences, King's College London, London, UK.

PubMed PMC DOI PDF

Abstract

OBJECTIVE: Outcome after surgical hematoma evacuation for intracerebral hemorrhage (ICH) depends on hematoma location. As corticospinal tract (CST) integrity affects motor recovery after stroke, we hypothesized that CST integrity drives heterogeneity in surgical outcomes and investigated this in a secondary analysis of MISTIE-III participants. METHODS: Risk of CST injury was categorized into four…

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