Integrating Genetic Testing, Combined Polygenic Risk, and Family History Assessment to Improve High-Risk Breast Cancer Identification in a Community Breast Imaging Center.

Tami Hudson¹, Shayna Giardina Leggett¹, Tammy McKamie², Laura Brzeskiewicz²

¹Singing River Health System, Mississippi, USA.

²Myriad Genetics, Utah, USA.

Abstract

OBJECTIVE: This initiative evaluated whether the Tyrer-Cuzick (TC) v8 model alone is sufficient for breast cancer (BC) risk assessment compared to a comprehensive strategy incorporating detailed family history intake, germline multigene panel testing, and a combined risk score (CRS) that integrates TC with a polygenic score validated for all ancestries. The aim was to determine whether this integr…

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