Incidence of outcomes relevant to vaccine safety monitoring in the general population, after influenza vaccination, and after respiratory infections: a descriptive analysis of four US claims databases, 2022-2023.

Christopher Bush¹, Shaina Desai¹, Huabo Wang², Wei-Chun Hsu³, E Claire Newbern³, Astra Toyip¹, Sarah Grace², Katherine E Mues¹, Brent Arakaki¹, Vaishali Khamamkar³, Daina B Esposito³, Cindy Ke Zhou⁴

¹Aetion, a Datavant Company, 1250 Broadway, New York, NY 10001, USA.

²CareJourney By Arcadia, 3865 Wilson Blvd #500, Arlington, VA 22203, USA.

³Moderna, Inc., 325 Binney Street, Cambridge, MA 02142, USA.

⁴Moderna, Inc., 325 Binney Street, Cambridge, MA 02142, USA. Electronic address: Cindy.Zhou@modernatx.com.

PubMed DOI

Abstract

BACKGROUND: Background incidence rates (IRs) of safety outcomes in the absence of vaccination of interest and IRs following the infection targeted by the vaccine, are integral for contextualizing vaccine benefit-risk. As new respiratory vaccines are developed, contemporaneous IR estimates for outcomes commonly assessed in vaccine safety surveillance are needed in the COVID-19 endemic era. METHODS…

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