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Peer-Reviewed Publication
J Am Heart Assoc2026;15(12):e048491.June 16, 2026Journal Article

Comprehensive Prestroke Risk Factor Control and Functional Outcomes After Acute Ischemic Stroke.

Joon-Tae Kim1, Ji Sung Lee2, Hyunsoo Kim1, Beom Joon Kim3, Jihoon Kang3, Keon-Joo Lee4, Jong-Moo Park5, Kyusik Kang6, Soo Joo Lee7, Jae Guk Kim7, Jae-Kwan Cha8, Dae-Hyun Kim8, Tai Hwan Park9, Kyungbok Lee10, Jeong-Yoon Lee10, Jun Lee11, Doo Hyuk Kwon11, Keun-Sik Hong12, Yong-Jin Cho12, Hong-Kyun Park12, Byung-Chul Lee13, Kyung-Ho Yu13, Mi Sun Oh13, Minwoo Lee13, Dong-Eog Kim14, Dong-Seok Gwak14, Jay Chol Choi15, Jee-Hyun Kwon16, Wook-Joo Kim16, Dong-Ick Shin17, Kyu Sun Yum17, Sung Il Sohn18, Jeong-Ho Hong18, Hyungjong Park18, Sang-Hwa Lee19, Chulho Kim19, Man-Seok Park1, Wi-Sun Ryu20, Kwang-Yeol Park21, Sung Hyuk Heo22, Juneyoung Lee23, Jeffrey L Saver24, Hee-Joon Bae3
1Department of Neurology Chonnam National University Hospital, Chonnam National University Medical School Gwangju Korea.
2Clinical Research Center, Asan Institute for Life Sciences Asan Medical Center, University of Ulsan College of Medicine Seoul Korea.
3Department of Neurology Seoul National University College of Medicine, Seoul National University Bundang Hospital Seongnam Korea.
4Department of Neurology Korea University Guro Hospital Seoul Korea.
5Department of Neurology Uijeongbu Eulji Medical Center, Eulji University School of Medicine Uijeongbu-si Korea.
6Department of Neurology Nowon Eulji Medical Center, Eulji University School of Medicine Seoul Korea.
7Department of Neurology Daejeon Eulji Medical Center, Eulji University School of Medicine Daejeon Korea.
8Department of Neurology Dong-A University Hospital Busan Korea.
9Department of Neurology Seoul Medical Center Seoul Korea.
10Department of Neurology Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine Seoul Korea.
11Department of Neurology Yeungnam University Hospital Daegu Korea.
12Department of Neurology Ilsan Paik Hospital, Inje University Goyang Korea.
13Department of Neurology Hallym University Sacred Heart Hospital Anyang Korea.
14Department of Neurology Dongguk University Ilsan Hospital Goyang Korea.
15Department of Neurology Jeju National University Hospital, Jeju National University School of Medicine Jeju Korea.
16Department of Neurology Ulsan University College of Medicine Ulsan Korea.
17Department of Neurology Chungbuk National University Hospital Cheongju Korea.
18Department of Neurology Keimyung University Dongsan Medical Center Daegu Korea.
19Department of Neurology Hallym University Chuncheon Sacred Heart Hospital Chuncheon-si Gangwon-do Korea.
20Artificial Intelligence Research Center JLK Inc. Seoul Korea.
21Department of Neurology Chung-Ang University College of Medicine, Chung-Ang University Hospital Seoul Korea.
22Department of Neurology Kyung Hee University Hospital Seoul Korea.
23Department of Biostatistics Korea University College of Medicine Seoul Korea.
24Department of Neurology and Comprehensive Stroke Center David Geffen School of Medicine, University of California Los Angeles CA USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Whether comprehensive prestroke risk factor (RF) management-defined by the extent to which existing major RFs meet prespecified treatment and biomarker criteria-is associated with 3-month functional outcomes after ischemic stroke remains unclear. METHODS: We analyzed patients with ischemic stroke from the CRCS-K-NIH (Clinical Research Collaborations for Stroke in Korea-National Instit…

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