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J Cardiovasc Comput Tomogr2026June 4, 2026Journal Article

Prediction of the Statin responders with radiomics.

Sang-Eun Lee1, Youngtaek Hong2, Juyeong Jung3, Ji Min Sung3, Daniele Andreini4, Mouaz H Al-Mallah5, Matthew J Budoff6, Filippo Cademartiri7, Kavitha Chinnaiyan8, Jung Hyun Choi9, Eun Ju Chun10, Edoardo Conte11, Ilan Gottlieb12, Martin Hadamitzky13, Yong Jin Kim14, Byoung Kwon Lee15, Jonathon A Leipsic16, Erica Maffei17, Hugo Marques18, Pedro de Araújo Gonçalves19, Gianluca Pontone20, Sanghoon Shin1, Peter H Stone21, Habib Samady22, Renu Virmani23, Jagat Narula24, Leslee J Shaw25, Jeroen J Bax26, Fay Y Lin25, James K Min27, Hyuk-Jae Chang28
1Division of Cardiology, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea.
2Department of Biomedical Engineering, College of Life Science & Biotechnology, Dongguk University, Goyang, South Korea.
3Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea.
4IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
5Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TX, USA.
6Department of Medicine, Lundquist Institute at Harbor-UCLA, Torrance, CA, USA.
7Department of Radiology, Fondazione Monasterio, Pisa, Italy.
8Department of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA.
9Pusan University Hospital, Busan, South Korea.
10Seoul National University Bundang Hospital, Seongnam, South Korea.
11Department of Clinical and Imaging Cardiology - Galeazzi-Sant'Ambrogio Hospital, Milan, Italy.
12Department of Radiology, Casa de Saude São Jose, Rio de Janeiro, Brazil.
13Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, Germany.
14Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea.
15Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
16Department of Medicine and Radiology, University of British Columbia, Vancouver, BC, Canada.
17Department of Radiology, Area Vasta 1/ Azienda Sanitaria Unica Regionale (ASUR) Marche, Urbino, Italy.
18UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisbon, Portugal.
19UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisbon, Portugal; Comprehensive Health Research Center (CHRC), LA-REAL, NOVA Medical School, Campo Mártires da Pátria, Lisboa, Portugal.
20Department of Biomedical, Dental and Surgical Sciences, University of Milan, Milan, Italy; Centro Cardiologico Monzino IRCCS, Milan, Italy.
21Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
22Georgia Heart Institute, Northeast Georgia Health System, Gainesville, GA, USA.
23Department of Pathology, CVPath Institute, Gaithersburg, MD, USA.
24University of Texas Health Houston, Houston, TX, USA.
25Icahn School of Medicine at Mount Sinai, New York, NY, USA.
26Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
27Cleerly, Inc, New York, NY, USA.
28Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. Electronic address: hjchang@yuhs.ac.
PubMed DOI

Abstract

BACKGROUND: Statins are a cornerstone medication for coronary atherosclerosis. This study assessed whether radiomic analysis of coronary computed tomography angiography (CCTA) could predict patient response to statin therapy. METHODS: Patients from a multinational registry with serial CCTA (≥2-year intervals) on statin therapy were analyzed. Radiomic scores were calculated, categorizing patients…

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